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This functional connection relies on the ability of mutant p53 to interactwith SMAD2 and p63, forming a ternary complex that blocks the role of p63 as ananti-metastatic factor. (2003) Theprognostic significance of subsyndromal delirium in elderlymedical inpatients. The infant begins to imitate sounds by 6 months.Combined syllables (“mama”) are vocalized by 8 months, andthe infant understands “no-no” by 9 months. In parallel with these epidemiologic studies, identifying a pathogen of ATL waschallenged and then HTLV-1 was discovered as the causative virus for ATL in early 1980s[15, 16] In parallel with these epidemiologic studies, identifying a pathogen of ATL waschallenged and then HTLV-1 was discovered as the causative virus for ATL in early 1980s[15, 16].
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